BloxPress — this is probably the first WP theme I’ve seen that heavily uses Ajax.
… a totally new type of theme with many interactive options for your visitors and also for you as webmaster. It’s expandable and offers much powerful functions and features never seen before in the WordPress Community. Enable your visitors to recreate their reading experience by customizing your website live with the power of AJAX in the back. Many new built-in plugins with interesting functions included, like “sticky notesâ€, “global bookmarks†and “off site content aggregationâ€, to name a few.
Much like MyYahoo! or NetVibes. Really cool theme. Check the demo version here.
My only concern about the theme is that it might not be very good when integrated with AdSense. If most of your content is delivered dynamically by Javascripts, AdSense may not be able to read it completely and deliver relevant/contextual ads.
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